1. Inhibitory Antibodies
  2. Omalizumab

Omalizumab  (Synonyms: 奥马珠单抗; Olizumab; rhuMab-E25)

目录号: HY-P9950 纯度: 99.70%
COA

Omalizumab 是一种针对人免疫球蛋白 E (IgE) 的重组人源化单克隆抗体,KD 为 0.393 nM。Omalizumab 结合人 FcγRIIb 受体,KD 为 6.37 uM。Omalizumab 具有用于持续性过敏性哮喘研究的潜力。

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CAS No. : 242138-07-4

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规格 价格 是否有货 数量
1 mg ¥1300
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5 mg ¥4500
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10 mg ¥6975
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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research[1][2].

体外研究
(In Vitro)

Omalizumab (0.1、0.5、1.0、2.0 μg/mL) 对 B 细胞有直接作用,可以减少 IL-4 加抗 CD40 处理的 B 细胞培养物中存在的膜 IgE+ 细胞数量。Omalizumab 单独对活细胞数没有影响[3]
Omalizumab (1 μg/mL;3、7 天) 减少人 B 细胞中 IL-6 的分泌。
Omalizumab 不会诱导人 B 细胞凋亡[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Omalizumab (10 mg/kg/天;腹腔注射;第 8 至 42 天) 增加移植人 PBMC 的严重联合免疫缺陷 (huSCID) 小鼠的 IgE 水平[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

固体

颜色

White to light yellow

中文名称

奥马珠单抗

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料

纯度: 99.70%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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